Impacts of chemically different surfaces of implants on a biological activity of fibroblast growth factor-2–apatite composite layers formed on the implants

Implants coated with fibroblast growth factor-2 (FGF-2)–apatite composite layers were previously reported to enhance soft-tissue formation, bone and angiogenesis around the implants owing biological activity of FGF-2. However, it is unclear whether chemistries material surface have some impact on retention FGF-2 in ? apatite them. Since magnitude should be evaluated for extensive application layer coat various implants, following items examined; (1) six (2) mitogenic activities FGF-2–apatite (3) improved synthesis method The affected by implants. Six commercial products pins screws having different layers. quantitatively analyzed calcium (Ca), phosphorus (P) FGF-2, also Improvement was then attempted using two pin products. Each product had a chemically morphologically characteristic surface. formed all Although Ca, P, contents (4.7 ± 0.9 ?g/mm, 2.2 0.4 21.1 3.7 ng/mm, respectively) Ca/P molar ratios (1.69 0.01) almost same, rate significantly decreased (3/12–4/12). decrease prevented two-step form precoating phosphate (9/12–12/12). implant surfaces significant implant. useful retain regardless has potential expand applicability wider range III, Case control vitro study.